Does CBD Oil Work for Migraines?

Does CBD Oil Work for Migraines?

CBD Oil for Migraines

Toward the conclusion regarding the nineteenth century, cannabis had been a main-stream treatment for preventing and relieving migraines as well as other forms of headaches. Numerous medical practioners advocated because of its use through to the 1940s, when cannabis had been taken from the formal pharmacopeias due to its “high possibility of abuse” 1+, 2.

The present legalization of medical marijuana and CBD oil in many nations worldwide revived the almost-forgotten utilization of cannabis for headaches. But, it’s important to see that the actual only real medical usage of CBD authorized because of the FDA would be to reduce seizures in 2 forms of epilepsy 3.

Migraines as well as other forms of headaches are, after joint disease, the conditions that are painful commonly improved with CBD oil. In a survey on 1500 medical CBD users, more or less one away from six reported suffering from headaches 4.

30% of medical cannabis users reported doing this to alleviate migraines along with other headaches in 2 studies on very nearly 2500 individuals. Nevertheless, probably the most popular variety among them had been “OG Shark,” a THC-rich hybrid strain with a low CBD content 5, 6.

This actually leaves us aided by the concern: does CBD oil alone relieve migraines as well as other forms of headaches or must you simply take THC-containing cannabis strains to obtain the pain-relieving advantages? Let’s look in the science of CBD first to obtain the responses.

How Exactly Does It Work?

Regardless of kind, headaches include an overactivation of nerves linked to arteries within the mind (trigeminovascular system) 2, 7+.

Released vessel-widening proteins (CGRP and substance P) and messengers (NO) enhance circulation, which stimulates discomfort receptors on neurological cells within the mind and throat. Headaches are a definite direct outcome of the stimulation, while medications for headaches frequently block these receptors 2, 7+.

Boosts Normal Cannabinoids

The system that is endocannabinoid composed of two receptors: CB1 and CB2. Both THC from cannabis plus the cannabinoids obviously generated by the physical human body, such as for example anandamide, relieve pain by activating these receptors 8, 10, 11.

CBD differs: it blocks instead of activates these receptors. Nonetheless, it prevents anandamide from being separated. Interestingly, a theory through the very early 21st century linked migraines (as well as other chronic pain conditions) with low anandamide levels 12, 10, 13, 14, 15.

In fact, further studies revealed that individuals – and specially women – with migraines frequently have less anandamide within the fluid that is spinal platelets 16, 17, 18.

The exact same ended up being real in individuals with headaches from overusing painkillers; after they withdrew through the medications, that they had less breakdown that is anandamide pain 19, 20.

Individuals with chronic headaches have reduced anandamide levels and greater CGRP and NO production. CB1 activation by anandamide and cannabinoids that are synthetic the manufacturing of CGRP with no, which prevents (trigeminovascular) nerve overstimulation and headaches 21, 22, 23, 24, 16.

Activates Serotonin Receptors

As hinted above, anandamide reduces migraines by activating CB1. In rats, blockers regarding the serotonin receptor 5HT(1B/1D) prevented anandamide from activating CB1. This receptor possesses role that is well-known relieving headaches and its own activators (called triptans) are traditional drugs for migraines 25, 26, 27.

CBD may reduce neurological discomfort by activating another serotonin receptor (5HT1A), which will be based in the spine as opposed to when you look at the mind 28|relative head28, 29, 30, 31.

Activates the TRPV1 Receptor

CBD and anandamide can bind to a receptor involved with inflammatory pain (TRPV1). Its activation causes the production of CGRP, which increases the flow of blood to your trigeminal nerves. This shows that CBD might cause headaches 14, 32, 33, 34, 35.

Nonetheless, repeated TRPV1 activation reduces sensitiveness to pain. Certainly, a nose spray because of the chili pepper compound capsaicin – which also activates this receptor – relieved migraines in a trial that is small 8 individuals 14, 36+.

Obstructs Glutamate

Alterations in eyesight, flexibility, or message called aura typically precede migraine assaults. These migraine harbingers are due to glutamate overactivation into the mind. Anandamide, THC, and cannabinoids that are synthetic glutamate receptors, suggesting they assist in preventing auras 2, 37, 38, 39, 40.

Reduces Inflammation and Autoimmunity

Autoimmune conditions may trigger migraines as well as other kinds of headaches when they result inflammation for the bloodstream within the mind. Certainly, conditions such as for example numerous sclerosis, lupus, Sjцgren problem, and antiphospholipid problem are connected with frequent headaches 41.

CBD may alleviate headaches in people who have these conditions through its strong activity that is anti-inflammatory. It decreases the manufacturing of pro-inflammatory messengers (such as for instance IL-1beta, IL-6, TNF-alpha, IFN-gamma. NO, and prostaglandins) while increasing the quantities of the anti-inflammatory cytokines IL-4 and IL-10 43, 44, 45, 46, 47.

Alternatively, it might probably avoid the apparent symptoms of autoimmune disorders by curbing the immune response. As an example, CBD prevented T cells from multiplying and building up into the minds of mice with multiple sclerosis – while reducing the autoimmune-linked Th17 reaction 48, 49.

Whenever Does It Work?


In a research on over 100 individuals with migraines using medicinal cannabis (with both CBD and THC), 85% reported paid down pain and frequency 50 that is migraine.

A preparation with more CBD than THC prevented attacks as effectively as a migraine drug (amitriptyline) in a clinical trial on 79 people with chronic migraines. a dose that is additional the assaults reduced pain. Likewise, 3 cannabis that are heavy started having migraines when they stopped; one got rest from smoking once again 51.

THC may account fully for a cbd oil part that is great of impacts. THC alone prevented attacks that are migraine paid off pain in rats. In comparison, its overuse could have the reverse impact: high doses increased sensitivity to repeated neurological stimulation – a suspected migraine trigger 53, 54.

Taken together, there isn’t any proof that CBD oil improves migraines. Studies in rats even claim that THC instead of CBD will be the cannabinoid accountable for the pain relief noticed in people utilizing cannabis preparations for migraines.

Other styles of Headaches

In a scholarly research on over 100 people who have group headaches, 45% utilized cannabis but just 25% skilled relief while 22percent felt even even worse 55.

Within one report, leisure marijuana and synthetic THC (dronabinol) enhanced regular cluster headaches in an adolescent. The power ended up being most likely from THC, maybe not CBD 56.

In an effort on 13 people who have headaches from overusing painkillers, cannabis preparations pain that is reduced. But, the planning with all the THC content that is highest (oil) was more efficient. In accordance with this, an artificial compound that is THCnabilone) reduced pain plus the importance of painkillers a lot better than ibuprofen in another test on 26 individuals 57, 58.

Into the temporary, THC as well as other CB1 activators additionally relieved headaches from painkillers in rats. But, their duplicated use increased sensitiveness to discomfort meaning that is might trigger migraines 54.

Both medical cannabis and a synthetic THC substance (dronabinol) relieved headaches in 2 females with high pressure into the brain (pseudotumor cerebri) 59+, 60.

A couple of clinical and animal studies recommend that CBD is perhaps inadequate for group headaches and headaches from overusing painkillers. THC is apparently the only cannabinoid providing some relief of pain, nevertheless the proof continues to be limited.


There are not any clinical studies testing CBD alone for headaches. A lot of them utilized cannabis preparations with adjustable quantities of THC and CBD.

A lot of people with migraines prefer THC-rich cannabis strains. Plus, synthetic THC analogs had been additionally effective. This shows that migraine relief requires direct activation that is CB1 only THC will probably attain. Having said that, CBD may help by boosting slightly anandamide levels.

CBD Oil Dosage for Migraines


Because CBD just isn’t authorized for migraines or other forms of headaches, there isn’t any formal dosage. There’s no proven dose either because CBD alone hasn’t been tested in medical studies. The only research assessing a item higher in CBD than in THC (9% vs 0.4%) utilized a dose of 200 mg (providing 18 mg CBD) a day. But, we can’t rule the contribution out of the THC content to your results 51+.

We could additionally calculate dose in line with the recommendations from manufacturers and users.

One maker of the oil that is commercial formulated for migraines recommends 1 mL (supplying 33 mg CBD) per day.

Natural health blog sites and users choose reduced doses (15-25 mg/day). They often suggest beginning with a low dosage and increasing it until observing pain-relieving effects. It’s crucial to achieve this slowly, since high doses may trigger migraines while increasing hassle intensity 61.

Whatever the case, don’t try CBD oil or just about any other unproven treatments for migraines and headaches without consulting your physician ahead of time. Consult with your physician if CBD oil might help available for you and just exactly what dose and delivery kind may be better for your needs.

How to utilize

CBD oil will come in various kinds. Your type of option may be determined by your sort of frustration 62+:

  • Vaping, lips sprays, and oil tinctures are consumed quickly and supply pain relief that is temporary. They may function better for cyclically-arising headaches such as for example group headaches.
  • Capsules, edibles, and teas release the CBD more gradually however their effects keep going longer. They might be better for conditions with constant pain such as for instance headaches from overusing painkillers.

Although migraine pain is certainly not constant, slow-release CBD types could be far better (predicated on CBD’s discussion with all the TRPV1 receptor). Acute CBD doses may trigger migraine assaults while duplicated doses decrease pain perception.

Anecdotal proof from internet forums advises using medicinal cannabis services and products soon after just starting to sense the start of a migraine or cluster hassle attack 61.

Most readily useful CBD Oil for Migraines

Along with picking a CBD oil adjusted to your allowance (you might want to determine the cost per mL or mg to compare different brands), it’s also wise to measure the item quality. Read here on how to select the best CBD oil.


The viewpoints expressed in this area are solely those of CBD oil users whom may or might not have medical or training that is scientific. Their reviews usually do not represent the viewpoints of SelfHacked. SelfHacked will not endorse any product that is specific solution, or therapy.

Try not to consider individual experiences as medical advice. Never ever postpone or disregard looking for expert advice that is medical your physician or other qualified healthcare providers as a result of one thing you’ve got continue reading SelfHacked. We realize that reading specific, real-life experiences may be a helpful resource, however it is never an alternative for professional medical advice, diagnosis, or therapy from the qualified doctor.

The absolute most headache that is common among CBD oil users ended up being migraine, followed closely by stress frustration, and hassle from painkiller overuse or conditions such as for instance fibromyalgia. Many of them had been satisfied and reported good pain alleviation. The users reported some added benefits such as improving sleep quality and curbing anxiety in several cases.

Some users reported that the oil didn’t work that it made them drowsy and fatigued for them or. CBD oil also caused headaches in certain people taking it at high doses.


Many people with migraines utilize THC-rich cannabis strains, while some choose CBD oil. No studies that are clinical yet tested CBD oil alone for headaches or migraines.

Animal studies reveal that CBD oil may alleviate headaches – but just when you look at the long haul and not likely along with THC.

Sudden surges in CBD, such as for example from vaping, could cause migraines. But taken long-lasting, CBD may decrease pain perception and stop migraine auras. It primarily functions by boosting your cannabinoid that is natural bliss.

CBD oil are often a choice if you have migraines and headaches from autoimmune diseases like lupus and sclerosis that is multiple. In these instances, it probably helps by reducing mind suppressing and inflammation autoimmunity.

Go with capsules or edibles and just just take them every time to find the best outcomes.

Vendors offer CBD oil on Amazon, but some of them usually do not satisfy quality criteria. Some don’t even specify the CBD content within their items, while others sell hemp oil with little or no CBD. Many of these vendors are never to be trusted.

We suggest the brand that is following which specifies quality procedures and CBD content within their services and products:

This area contains sponsored links, meaning that we possibly may get a tiny portion for the earnings from your own purchase, even though the cost remains the exact same for your requirements. The arises from your purchase support our research and work. Thank you for the help!

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